Papers

Human-specific NOTCH2NL genes expand cortical neurogenesis through Delta/Notch regulation.

Human-specific NOTCH2NL genes expand cortical neurogenesis through Delta/Notch regulation. Suzuki IK, Gacquer D, Van Heurck R, Kumar D, Wojno M, Bilheu A, Herpoel A, Cheron J, Polleux F, Detours V, and Vanderhaeghen P. Cell. 2018 May 31;173(6):1370-1384.  
https://www.cell.com/cell/fulltext/S0092-8674(18)30399-4

Human Pluripotent Stem-Cell-Derived Cortical Neurons Integrate Functionally into the Lesioned Adult Murine Visual Cortex in an Area-Specific Way.

Human Pluripotent Stem-Cell-Derived Cortical Neurons Integrate Functionally into the Lesioned Adult Murine Visual Cortex in an Area-Specific Way. Espuny-Camacho I, Michelsen KA, Linaro D, Bilheu A, Acosta-Verdugo S, Herpoel A, Giugliano M, Gaillard A, Vanderhaeghen P. Cell Reports. 2018 May 29;23(9):2732-2743.
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30672-7

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain. Espuny-Camacho I, Arranz AM, Fiers M, Snellinx A, Ando K, Munck S, Bonnefont J, Lambot L, Corthout N, Omodho L, Vanden Eynden E, Radaelli E, Tesseur I, Wray S, Ebneth A, Hardy J, Leroy K, Brion JP, Vanderhaeghen P*, De Strooper B*. *Co-Senior authors. Neuron (2017) 93(5):1066-1081. https://www.cell.com/neuron/fulltext/S0896-6273(17)30058-2
https://www.cell.com/neuron/fulltext/S0896-6273(17)30058-2

Area-specific reestablishment of damaged circuits in the adult cerebral cortex

Area-specific reestablishment of damaged circuits in the adult cerebral cortex by cortical neurons derived from mouse embryonic stem cells. Michelsen KA , Acosta-Verdugo P, Benoit-Marand M, Espuny-Camacho I, Gaspard N, Saha B, Gaillard A , Vanderhaeghen P. Neuron (2015), 85(5):982-97. https://www.cell.com/neuron/fulltext/S0896-6273(15)00090-2
https://www.cell.com/neuron/fulltext/S0896-6273(15)00090-2

Is this a brain which I see before me? Modelling human neural development with pluripotent stem cells.

Is this a brain which I see before me? Modelling human neural development with pluripotent stem cells. Suzuki I, and Vanderhaeghen P. Development (2015),142(18):3138-50. http://dev.biologists.org/content/142/18/3138.long
http://dev.biologists.org/content/142/18/3138.long

A BCL6/BCOR/SIRT1 complex Triggers Neurogenesis and Suppresses Medulloblastoma by Repressing Sonic Hedgehog Signalling.

A BCL6/BCOR/SIRT1 complex Triggers Neurogenesis and Suppresses Medulloblastoma by Repressing Sonic Hedgehog Signalling. Tiberi L, Bonnefont J, van den Ameele J, Le Bon S, Herpoel A, Bilheu A, Baron BW, Vanderhaeghen P. Cancer Cell (2014) 26, 797-812. https://www.cell.com/cancer-cell/fulltext/S1535-6108(14)00451-6
https://www.cell.com/cancer-cell/fulltext/S1535-6108(14)00451-6

Thinking out of the dish: what to learn about cortical development using pluripotent stem cells.

Thinking out of the dish: what to learn about cortical development using pluripotent stem cells. van den Ameele, J., Tiberi, L., Vanderhaeghen, P*., and Espuny-Camacho, I. *corresponding author. Trends Neurosci. (2014), 37, 334-342. https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(14)00044-7  
https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(14)00044-7

Pyramidal neurons generated from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo.

Pyramidal neurons generated from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo. Espuny-Camacho I, Michelsen K, Gall D, Linaro D, Hasche A, Bonnefont J, Bali C, Orduz D, Bilheu A, Herpoel A, Lambert N, Gaspard N, Péron S, Schiffmann SN, Giugliano M, Gaillard A, and Vanderhaeghen P. Neuron (2013), 77, 440-456. https://www.cell.com/neuron/fulltext/S0896-6273(12)01121-X
https://www.cell.com/neuron/fulltext/S0896-6273(12)01121-X

BCL6 induces neurogenesis through Sirt1-dependent epigenetic repression of selective Notch transcriptional targets.

BCL6 induces neurogenesis through Sirt1-dependent epigenetic repression of selective Notch transcriptional targets. Tiberi, L., van den Ameele, J., Dimidschstein, J., Piccirilli, J., Gall, D., Herpoel, A., Bilheu, A., Bonnefont, J., Iacovino, M., Kyba, M., Bouschet T., and Vanderhaeghen P. Nature Neurosci. (2012), 15, 1627-1635. https://www.nature.com/articles/nn.3264
https://www.nature.com/articles/nn.3264

Generation of Cortical Neurons from Embryonic Stem Cells. Gaspard N, Bouschet T, Herpoel A, Naeije G, vandenAmeele J, and Vanderhaeghen P.

Generation of Cortical Neurons from Embryonic Stem Cells. Gaspard N, Bouschet T, Herpoel A, Naeije G, vandenAmeele J, and Vanderhaeghen P. Nature Protocols  4 (2009), 1454-63. https://www.nature.com/articles/nprot.2009.157
https://www.nature.com/articles/nprot.2009.157

An intrinsic mechanism of corticogenesis from embryonic stem cells.

An intrinsic mechanism of corticogenesis from embryonic stem cells. Gaspard N, Bouschet T, Hourez R, Dimidschstein J, Naeije G, vandenAmeele J, Espuny-Camacho I, Herpoel A, Passante L, Schiffmann S, Gaillard A, and Vanderhaeghen P. Nature  455 (2008), 351-357. https://www.nature.com/articles/nature07287
https://www.nature.com/articles/nature07287