Papers

LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons

Baptiste Libé-Philippot,A mélie Lejeune, Keimpe Wierda,Nikolaos Louros,Emir Erkol,Ine Vlaeminck,Sofie Beckers,Vaiva Gaspariunaite,Angéline Bilheu,Katerina Konstantoulea,Hajnalka Nyitrai,Matthias De Vleeschouwer,Kristel M. Vennekens,Niels Vidal,Thomas W. Bird,Daniela C. Soto,Tom Jaspers,Maarten Dewilde,Megan Y. Dennis,Frederic Rousseau,D avide Comoletti, Joost Schymkowitz,Tom Theys, Joris de Wit*, Pierre Vanderhaeghen*. Cell (2023) 186, 5766-5783.
https://www.cell.com/cell/pdf/S0092-8674(23)01314-4.pdf

Mitochondria metabolism sets the species-specific tempo of neuronal development.

Iwata R*, Casimir P*, Erkol E, Boubakar L, Planque M, Gallego López IM, Ditkowska M, Gaspariunaite V, Beckers S, Remans D, Vints K, Vandekeere A, Poovathingal S, Bird M, Vlaeminck I, Creemers E, Wierda K, Corthout N, Vermeersch P, Carpentier S, Davie K, Mazzone M, Gounko NV, Aerts S, Ghesquière B, Fendt SM, Vanderhaeghen P. Science. 2023 Feb 10;379(6632):eabn4705.
https://www.science.org/stoken/author-tokens/ST-993/full

Developmental mechanisms underlying the evolution of human cortical circuits

Vanderhaeghen P, Polleux F. Nature Reviews Neuroscience 2023. https://doi.org/10.1038/s41583-023-00675-z  
https://rdcu.be/c5Hqn

CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors

Van Heurck R*, Bonnefont J*, Wojno M, Suzuki IK, Velez-Bravo FD, Erkol E, Nguyen DT, Herpoel A, Bilheu A, Beckers S, Ledent C, Vanderhaeghen P. Neuron. 2023 Jan 4;111(1):65-80.e6. doi: 10.1016/j.neuron.2022.10.018. Epub 2022 Nov 4.
https://www.cell.com/neuron/fulltext/S0896-6273(22)00947-3

Xenotransplanted human cortical neurons reveal species-specific development and functional integration into mouse visual circuits.

Linaro D, Vermaercke B, Iwata R, Ramaswamy A, Davis B, Boubakar L, Libé-Philippot B, Bilheu A, De Bruyne L, Gall D, Conzelmann K, Bonin V, Vanderhaeghen P. Neuron (2019), Neuron 104, 972–986.
https://www.cell.com/neuron/fulltext/S0896-6273(19)30850-5

Bcl6 promotes neurogenic conversion through transcriptional repression of multiple self-renewal-promoting extrinsic pathways.

Bonnefont J, Tiberi L, van den Ameele J,  Potier D, Gaber Z,  Lin X,  Bilheu A,  Herpoel A,  Velez Bravo FD,  Guillemot F, Aerts S, Vanderhaeghen P. Neuron (2019), 103, 1096-1108. 
https://www.cell.com/neuron/fulltext/S0896-6273(19)30597-5

Human-specific NOTCH2NL genes expand cortical neurogenesis through Delta/Notch regulation.

Human-specific NOTCH2NL genes expand cortical neurogenesis through Delta/Notch regulation. Suzuki IK, Gacquer D, Van Heurck R, Kumar D, Wojno M, Bilheu A, Herpoel A, Cheron J, Polleux F, Detours V, and Vanderhaeghen P. Cell. 2018 May 31;173(6):1370-1384.  
https://www.cell.com/cell/fulltext/S0092-8674(18)30399-4

Human Pluripotent Stem-Cell-Derived Cortical Neurons Integrate Functionally into the Lesioned Adult Murine Visual Cortex in an Area-Specific Way.

Human Pluripotent Stem-Cell-Derived Cortical Neurons Integrate Functionally into the Lesioned Adult Murine Visual Cortex in an Area-Specific Way. Espuny-Camacho I, Michelsen KA, Linaro D, Bilheu A, Acosta-Verdugo S, Herpoel A, Giugliano M, Gaillard A, Vanderhaeghen P. Cell Reports. 2018 May 29;23(9):2732-2743.
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30672-7

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain. Espuny-Camacho I, Arranz AM, Fiers M, Snellinx A, Ando K, Munck S, Bonnefont J, Lambot L, Corthout N, Omodho L, Vanden Eynden E, Radaelli E, Tesseur I, Wray S, Ebneth A, Hardy J, Leroy K, Brion JP, Vanderhaeghen P*, De Strooper B*. *Co-Senior authors. Neuron (2017) 93(5):1066-1081. https://www.cell.com/neuron/fulltext/S0896-6273(17)30058-2
https://www.cell.com/neuron/fulltext/S0896-6273(17)30058-2

Area-specific reestablishment of damaged circuits in the adult cerebral cortex

Area-specific reestablishment of damaged circuits in the adult cerebral cortex by cortical neurons derived from mouse embryonic stem cells. Michelsen KA , Acosta-Verdugo P, Benoit-Marand M, Espuny-Camacho I, Gaspard N, Saha B, Gaillard A , Vanderhaeghen P. Neuron (2015), 85(5):982-97. https://www.cell.com/neuron/fulltext/S0896-6273(15)00090-2
https://www.cell.com/neuron/fulltext/S0896-6273(15)00090-2

Is this a brain which I see before me? Modelling human neural development with pluripotent stem cells.

Is this a brain which I see before me? Modelling human neural development with pluripotent stem cells. Suzuki I, and Vanderhaeghen P. Development (2015),142(18):3138-50. http://dev.biologists.org/content/142/18/3138.long
http://dev.biologists.org/content/142/18/3138.long

A BCL6/BCOR/SIRT1 complex Triggers Neurogenesis and Suppresses Medulloblastoma by Repressing Sonic Hedgehog Signalling.

A BCL6/BCOR/SIRT1 complex Triggers Neurogenesis and Suppresses Medulloblastoma by Repressing Sonic Hedgehog Signalling. Tiberi L, Bonnefont J, van den Ameele J, Le Bon S, Herpoel A, Bilheu A, Baron BW, Vanderhaeghen P. Cancer Cell (2014) 26, 797-812. https://www.cell.com/cancer-cell/fulltext/S1535-6108(14)00451-6
https://www.cell.com/cancer-cell/fulltext/S1535-6108(14)00451-6

Thinking out of the dish: what to learn about cortical development using pluripotent stem cells.

Thinking out of the dish: what to learn about cortical development using pluripotent stem cells. van den Ameele, J., Tiberi, L., Vanderhaeghen, P*., and Espuny-Camacho, I. *corresponding author. Trends Neurosci. (2014), 37, 334-342. https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(14)00044-7  
https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(14)00044-7

Pyramidal neurons generated from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo.

Pyramidal neurons generated from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo. Espuny-Camacho I, Michelsen K, Gall D, Linaro D, Hasche A, Bonnefont J, Bali C, Orduz D, Bilheu A, Herpoel A, Lambert N, Gaspard N, Péron S, Schiffmann SN, Giugliano M, Gaillard A, and Vanderhaeghen P. Neuron (2013), 77, 440-456. https://www.cell.com/neuron/fulltext/S0896-6273(12)01121-X
https://www.cell.com/neuron/fulltext/S0896-6273(12)01121-X

BCL6 induces neurogenesis through Sirt1-dependent epigenetic repression of selective Notch transcriptional targets.

BCL6 induces neurogenesis through Sirt1-dependent epigenetic repression of selective Notch transcriptional targets. Tiberi, L., van den Ameele, J., Dimidschstein, J., Piccirilli, J., Gall, D., Herpoel, A., Bilheu, A., Bonnefont, J., Iacovino, M., Kyba, M., Bouschet T., and Vanderhaeghen P. Nature Neurosci. (2012), 15, 1627-1635. https://www.nature.com/articles/nn.3264
https://www.nature.com/articles/nn.3264

An intrinsic mechanism of corticogenesis from embryonic stem cells.

An intrinsic mechanism of corticogenesis from embryonic stem cells. Gaspard N, Bouschet T, Hourez R, Dimidschstein J, Naeije G, vandenAmeele J, Espuny-Camacho I, Herpoel A, Passante L, Schiffmann S, Gaillard A, and Vanderhaeghen P. Nature  455 (2008), 351-357. https://www.nature.com/articles/nature07287
https://www.nature.com/articles/nature07287