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Metabolic mechanisms of species-specific developmental tempo
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Linking mitochondria metabolism, developmental timing, and human brain evolution
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LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons
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Developmental mechanisms underlying the evolution of human cortical circuits
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CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors
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Studying human neural function in vivo at the cellular level: Chasing chimeras?
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Cell. 2022 Dec 22;185(26):4869-4872. doi: 10.1016/j.cell.2022.11.020.
Cellular and Molecular Mechanisms Linking Human Cortical Development and Evolution.
Libé-Philippot B, Vanderhaeghen P.
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Mitochondrial dynamics in postmitotic cells regulate neurogenesis.
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Tempus fugit: How time flies during development.
Iwata R, Vanderhaeghen P.
Science. 2020 Sep 18;369(6510):1431-1432.
Xenotransplanted human cortical neurons reveal species-specific development and functional integration into mouse visual circuits.
Linaro D, Vermaercke B, Iwata R, Ramaswamy A, Davis B, Boubakar L, Libé-Philippot B, Bilheu A, De Bruyne L, Gall D, Conzelmann K, Bonin V, Vanderhaeghen P.
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Bcl6 promotes neurogenic conversion through transcriptional repression of multiple self-renewal-promoting extrinsic pathways.
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Neuron (2019), 103, 1096-1108.
Human-specific NOTCH2NL genes expand cortical neurogenesis through Delta/Notch regulation.
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Cell. 2018 May 31;173(6):1370-1384.
Human Pluripotent Stem-Cell-Derived Cortical Neurons Integrate Functionally into the Lesioned Adult Murine Visual Cortex in an Area-Specific Way.
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Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.
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Is this a brain which I see before me? Modelling human neural development with pluripotent stem cells.
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A BCL6/BCOR/SIRT1 complex Triggers Neurogenesis and Suppresses Medulloblastoma by Repressing Sonic Hedgehog Signalling.
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Thinking out of the dish: what to learn about cortical development using pluripotent stem cells.
Thinking out of the dish: what to learn about cortical development using pluripotent stem cells.
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Pyramidal neurons generated from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo.
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Neuron (2013), 77, 440-456.
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BCL6 induces neurogenesis through Sirt1-dependent epigenetic repression of selective Notch transcriptional targets.
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Regulatory roles of mitochondria and metabolism in neurogenesis
Iwata R, Vanderhaeghen P.
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An intrinsic mechanism of corticogenesis from embryonic stem cells.
An intrinsic mechanism of corticogenesis from embryonic stem cells.
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Nature 455 (2008), 351-357.
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