WELCOME TO OUR LAB!

Stem cell and Developmental neurobiology. Pierre Vanderhaeghen Lab.

FROM STEM CELLS TO NEURAL CIRCUITS :

DEVELOPMENT AND EVOLUTION OF THE HUMAN CEREBRAL CORTEX.

The cerebral cortex is arguably the most complex and important structure in our brain, and contributes in an essential way to who we are, as a species and as individuals.

The major research goal in our laboratory is to unravel some of the key mechanisms controlling the development of the cerebral cortex, from stem cells to neuronal circuits, in link with human brain evolution and diseases.

OUR PROJECTS

INTRODUCTION

INTRODUCTION

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Microcephaly genes / linking neurogenesis and evolution of brain size

Microcephaly genes / linking neurogenesis and evolution of brain size

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Human-specific genes, cortical development, and brain evolution.

Human-specific genes, cortical development, and brain evolution.

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Mechanisms controlling the timing of human neuronal maturation: the cellular basis of human brain neoteny.

Mechanisms controlling the timing of human neuronal maturation: the cellular basis of human brain neoteny.

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Modeling of neurodevelopmental disorders in human neurons in vivo.

Modeling of neurodevelopmental disorders in human neurons in vivo.

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Function and plasticity of transplanted human neurons: from circuit development to brain repair.

Function and plasticity of transplanted human neurons: from circuit development to brain repair.

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Papers

Human-specific NOTCH2NL genes expand cortical neurogenesis through Delta/Notch regulation.

Human-specific NOTCH2NL genes expand cortical neurogenesis through Delta/Notch regulation. Suzuki IK, Gacquer D, Van Heurck R, Kumar D, Wojno M, Bilheu A, Herpoel A, Cheron J, Polleux F, Detours V, and Vanderhaeghen P. Cell. 2018 May 31;173(6):1370-1384.  

https://www.cell.com/cell/fulltext/S0092-8674(18)30399-4

Human Pluripotent Stem-Cell-Derived Cortical Neurons Integrate Functionally into the Lesioned Adult...

Human Pluripotent Stem-Cell-Derived Cortical Neurons Integrate Functionally into the Lesioned Adult Murine Visual Cortex in an Area-Specific Way. Espuny-Camacho I, Michelsen KA, Linaro D, Bilheu A, Acosta-Verdugo S, Herpoel A, Giugliano M, Gaillard A, Vanderhaeghen P. Cell Reports. 2018 May 29...

https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30672-7

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain. Espuny-Camacho I, Arranz AM, Fiers M, Snellinx A, Ando K, Munck S, Bonnefont J, Lambot L, Corthout N, Omodho L, Vanden Eynden E, Radaelli E, Tesseur I, Wray S, Ebneth A, Hardy J, Leroy K, Brion...

https://www.cell.com/neuron/fulltext/S0896-6273(17)30058-2

Area-specific reestablishment of damaged circuits in the adult cerebral cortex

Area-specific reestablishment of damaged circuits in the adult cerebral cortex by cortical neurons derived from mouse embryonic stem cells. Michelsen KA , Acosta-Verdugo P, Benoit-Marand M, Espuny-Camacho I, Gaspard N, Saha B, Gaillard A , Vanderhaeghen P. Neuron (2015), 85(5):982-97. h...

https://www.cell.com/neuron/fulltext/S0896-6273(15)00090-2

OUTREACH

PRESS & MEDIA

Coverage on Suzuki Cell 2018 in the Economist

Link

Coverage on Suzuki 2018 in The New Scientist

Link

Coverage on Suzuki 2018 in Le Soir

Link

Coverage on Suzuki 2018 in Science magazine

Link

Coverage on Suzuki 2018 in VRT

Link

Coverage on Suzuki 2018 in Het laatste nieuws

Link

Our lab is part of the VIB-KULeuven Centre for Brain and Disease Research, Department of Neurosciences, Leuven Brain Institute, at KULeuven, and of IRIBHM, ULB, Brussels.

CONTACT

PIERRE VANDERHAEGHEN

MD, PhD

Stem Cell and Developmental Neurobiology Lab
VIB-KU Leuven Center for Brain & Disease Research
Department of Neurosciences, Leuven Brain Institute
O&N4 Herestraat 49 box 602 | 3000 Leuven | Belgium

Email : pierre.vanderhaeghen@kuleuven.vib.be